CASES FOR DIAGNOSIS Nodules on the Legs
نویسنده
چکیده
Histology revealed an atypical, densely cellular lymphoid infiltrate with a follicular growth pattern in the dermis and subcutaneous tissue (Figure 2). The infiltrate was composed of large cells resembling centroblasts or immunoblasts. Mitotic figures were common and the mitotic index was high. The immunohistochemical study was strongly positive for CD20, BCL-2 (Figure 3), and MUM-1/IRF4; weakly positive for BCL-6; and negative for T, CD30, and CD10 markers. Monoclonal rearrangement of immunoglobulin heavy chains was not detected by polymerase chain reaction. The t(14;18) translocation was also not found by polymerase chain reaction or fluorescence in situ hybridization. CASES FOR DIAGNOSIS
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